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    Only 22 of 75 age group had ECOG 0?.MortalityTable 1 CML demographics in Lithuania in 2000?Demographics Calendar period 2000?004 N Total Age, years Median Variety 0?4 45?four 55?four 65?four 75+ Gender Male Female 139 124 53 47 108 104 14a 51 49 66 60 7b 52 48 313 288 52 48 65 5?4 60 28 41 78 56 23 11 16 30 21 63 9?0 44 36 31 49 52 21 17 15 23 25 58 17?4 35 19 26 23 23 28 15 21 18 18 62 five?four 139 83 98 150 131 23 14 16 25 22 263 44 2005?009 N 212 35 2010?013 N 126 21 N 601 100 TotalThroughout the entire 2000?013 period the average VorapaxarMedChemExpress Vorapaxar mortality CR and ASR (W) have been 0.78 (variety 0.26?1.08) and 0.46 (range 0.13?.72), respectively. The typical mortality CR and ASR (W) decreased from 0.82 to 0.69 and from 0.47 to 0.38, respectively, comparing 2000?004 and 2010?013 periods. Although there was no important distinction in crude male and female mortality rates (p = 0.095), males had a greater general ASR (W) mortality (p = 0.014) (Table two). Older age was a powerful factor for greater mortality CR all through all time periods (p < 0.001 for all periods) (Additional file 1: Table S4).Survival trendsHematopoietic stem cell transplantation Allogeneica2 patients with double haematopoietic stem cell dar.12324 transplant (HSCT) b 1 patient dar.12324 with double HSCTThe RSR improved with every calendar period of therapy. General, 1-, 5- and 10-year RSRs had been 0.72, 0.49 and 0.36, respectively. RSR trends among males and females have been similar throughout the complete follow-up period (p = 0.697) (Table 3). Age was an essential predictor of RSR, with younger sufferers getting substantially superior RSR than elderly. 1-year RSR has markedly enhanced from 0.61 [95 CI, 0.55?.67] in 2000?004 to 0.81 [95 CI, 0.74?.86] in 2005?009, but plateaued at 0.81 [95 CI, 0.74?.86] throughout the 2010?013 period (Table three).Beinortas et al. BMC Cancer (2016) 16:Page 4 ofTable two CML epidemiology in Lithuania in 2000?Epidemiology Calendar period 2000?004 Male Incidence rate CR ASR (W) Mortality rate CR ASR (W) 0.98 0.62 0.68 0.38 0.82 0.47 0.83 0.61 0.80 0.46 0.82 0.52 0.82 0.52 0.58 0.29 0.69 0.38 0.89 0.59 0.69 0.38 0.78 0.46 1.72 1.20 1.34 0.87 1.51 1.00 1.37 1.00 1.15 0.72 1.25 0.86 1.17 0.88 0.91 0.65 1.03 0.75 1.44 1.04 1.15 0.76 1.28 0.88 Female All 2005?009 Male Female All 2010?013 Male Female All 2000?013 Male Female AllASR (W) age-standardized (weighted) price, CR crude rateA 5-year CML RSR increased from 0.33 [95 CI, 0.27?.40] in 2000?004 to 0.55 [95 CI, 0.47?.63] in 2005?009 period in Lithuania. All patient groups, but these above 75, have demonstrated an increase in 5-year RSR. A 10-year RSR for the general cohort was 0.36 [95 CI, 0.31?.42]. Fi.